2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1833):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-21286
    N2-Isobutyryl-2'-O-methylguanosine
    		99.97%
    N2-Isobutyryl-2'-O-methylguanosine (N2-IBU-2'-OME-RG) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N2-Isobutyryl-2'-O-methylguanosine
  • HY-W013195
    8-Bromoadenosine
    		99.68%
    8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. 8-Bromoadenosine can quench the intrinsic fluorescence of human serum albumin (HSA) through static quenching procedure. 8-Bromoadenosine can be used to synthesize adenosine phosphate, such as Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    8-Bromoadenosine
  • HY-128671
    6-​Thioinosine
    		99.31%
    6-​Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα.
    6-​Thioinosine
  • HY-135780A
    3'-Deoxyuridine-5'-triphosphate trisodium
    		99.69%
    3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM.
    3'-Deoxyuridine-5'-triphosphate trisodium
  • HY-W011548
    2-Aminoadenosine
    		≥98.0%
    2-Aminoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2-Aminoadenosine
  • HY-111646
    N6-Etheno 2'-deoxyadenosine
    		99.48%
    N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.
    N6-Etheno 2'-deoxyadenosine
  • HY-W093086
    DMT-2'-F-Bz-dA
    		99.58%
    DMT-2'-F-Bz-dA can be used in the synthesis of nucleotides and nucleic acids.
    DMT-2'-F-Bz-dA
  • HY-20140
    5'-O-DMT-dT
    		99.09%
    5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides.
    5'-O-DMT-dT
  • HY-N0157S1
    Orotic acid-13C,15N2 monohydrate
    		99.93%
    Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats.
    Orotic acid-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub> monohydrate
  • HY-17026R
    Gemcitabine (Standard)
    		Inhibitor 99.99%
    Gemcitabine (Standard) is the analytical standard of Gemcitabine. This product is intended for research and analytical applications. Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
    Gemcitabine (Standard)
  • HY-21545
    5'-O-DMT-Bz-rA
    		≥98.0%
    5'-O-DMT-Bz-rA is an intermediate for cyclic di-nucleotide compounds synthesis.
    5'-O-DMT-Bz-rA
  • HY-116887
    N6-Methyladenine
    		98.79%
    N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication.
    N6-Methyladenine
  • HY-154253
    5-Azidomethyl-2'-deoxyuridine
    		99.67%
    5-Azidomethyl-2'-deoxyuridine (5-AmdU) is a purine nucleoside analog. 5-Azidomethyl-2'-deoxyuridine demonstrates effective radiosensitization in EMT6 tumor cells.. 5-Azidomethyl-2'-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5-Azidomethyl-2'-deoxyuridine
  • HY-W089288
    2'-F-Bz-A
    		99.92%
    2'-F-Bz-A (N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
    2'-F-Bz-A
  • HY-B0003S
    Gemcitabine-13C,15N2 hydrochloride
    		99.80%
    Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
    Gemcitabine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub> hydrochloride
  • HY-109014
    Tenofovir exalidex
    		99.82%
    Tenofovir exalidex (CMX157) is a lipid conjugate of the acyclic nucleotide analog Tenofovir with activity against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. Tenofovir exalidex is active against all major subtypes of HIV-1 and HIV-2 in fresh human PBMCs and against all HIV-1 strains evaluated in monocyte-derived macrophages, with EC50s ranging between 0.2 and 7.2 nM. CMX157 is orally available and has no apparent toxicity. Tenofovir exalidex also shows antiviral activity against HBV.
    Tenofovir exalidex
  • HY-W009016
    2’,3’,5’-Tri-O-acetyl adenosine
    		99.55%
    2’,3’,5’-Tri-O-acetyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2’,3’,5’-Tri-O-acetyl adenosine
  • HY-154147
    2’-Deoxy-N1-methylguanosine
    		99.56%
    2’-Deoxy-N1-methylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-N1-methylguanosine
  • HY-14941
    Elacytarabine
    		≥98.0%
    Elacytarabine (CP 4055) is a lipid-conjugated derivative of the nucleoside analog cytarabine. Elacytarabine (CP 4055) is an antineoplastic agent with cytotoxicity in solid tumors.
    Elacytarabine
  • HY-W011168
    8-Bromo-2'-deoxyguanosine
    		≥98.0%
    8-Bromo-2'-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Bromo-2'-deoxyguanosine